Figure 1.

Composition of the 8–17 and 10–23 catalytic motifs. The DNAzyme (lower strand) binds the RNA substrate (top strand) through Watson–Crick pairing. Cleavage occurs at the position indicated by the arrow. R = A or G; Y = U or C

Composition of the 8–17 and 10–23 catalytic motifs. The DNAzyme (lower strand) binds the RNA substrate (top strand) through Watson–Crick pairing. Cleavage occurs at the position indicated by the arrow. R = A or G; Y = U or C