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In vitro cleavage of SARS‐CoV 5′UTR by DNAzyme‐104. (A) Gel analysis of the cleaved product with Dz‐104 (upper panel) and Dz‐104 (mut) (lower panel). S, substate RNA; P, cleavage products. (B) Kinetic profile of DNAzyme‐104 under single turnover conditions with a 10‐fold enzyme excess. (C) Kinetic profile of DNAzyme‐104 under multiple turnover conditions with a 10‐fold substrate excess. Y axis represents the % of cleaved product
