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. 2020 Mar 3;92(5):512–517. doi: 10.1002/jmv.25715

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Published 2020. This article is a U.S. Governmaent work and is in the public domain in the USA.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Geometric mean titers (GMT) of antibodies by two methods to human coronaviruses (HCoV) ‐229E, ‐NL63, ‐OC43, and ‐HKU1 are shown by age group (15 serum pairs from group 1 subjects who were 60‐85 years of age and 28 serum pairs from group 2 subjects who were 21‐40 years of age) and by time of serum collection (acute, collected within five days of onset of acute respiratory illness, and convalescent, collected 3‐4 weeks later). “All visits” refer to the GMT of both acute and convalescent sera together by the patient subject group. The tick marks at the ends of the vertical lines show the corresponding 25th and 75th percentile antibody levels above and below the GMT to indicate a measure of interpatient variability, IgG binding antibody GMT measured by enzyme‐linked immunosorbent assay (ELISA) are shown in panel A and neutralizing antibody GMT are shown in panel B, categorized by reactivity to the respective HCoV strains. IgG, immunoglobulin G