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. 2009 Jan 21;106(4):682–692. doi: 10.1002/jcb.22065

Figure 2.

Figure 2

Endogenous Notch signaling is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells. A: In the presence or absence of 100 µM DAPT, K562/CBF1‐RE‐Luc cells were treated with various concentrations of baicalin (left), baicalein (middle), and niclosamide (right) for 24 h. B: After seeding of K562/CBF1‐RE‐Luc cells at the same time, cells were treated with 100 µM DAPT for various periods of time and then harvested for reporter gene assay. In the presence or absence of 100 µM DAPT, K562/CBF1‐RE‐Luc cells were also treated with 100 µM baicalin, 10 µM baicalein, and 1.25 µM niclosamide for various periods of time and then harvested for reporter gene assay. Luciferase reporter gene activity was determined as described in the legend to Figure 1. *P < 0.05; **P < 0.01; ***P < 0.001 compared with vehicle.