Table 2.
Correlation analysis between region‐specific genes and cardiac‐related diseases
| Gene* | Gene full name | Cardiac‐related diseases ** | Region | |
|---|---|---|---|---|
| ACADVL * | Acyl‐CoA Dehydrogenase, Very Long Chain | Hypertrophic cardiomyopathy; cardiac arrest; cardiomyopathies; sudden cardiac death; | Vessel | |
| ALDH1B1 | Aldehyde Dehydrogenase 1 Family Member B1 | Coronary heart disease; coronary artery disease | Vessel | |
| BCKDHB | Branched Chain Keto Acid Dehydrogenase E1 Subunit Beta | Multiple myeloma | Vessel | |
| CS | Citrate Synthase | Cerebrovascular accident; angiomatosis, bacillary; cataract and cardiomyopathy; heart failure; cardiomyopathies | Vessel | |
| DLAT | Dihydrolipoamide S‐acetyltransferase | Myocardial Ischemia | Vessel | |
| ENO1 | Enolase 1 | Left ventricular hypertrophy; bacterial endocarditis; myocardial infarction; Behcet syndrome; acute coronary syndrome *** | Vessel | |
| FN1 | Fibronectin 1 | Myocardial infarction; left ventricular hypertrophy; increase in blood pressure; aortic valve insufficiency; hypertensive disease | Vessel | |
| IDH1 | Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic | Venous thrombosis; vascular neoplasms; hemangioma; hemangiomatosis; visceral angiomatosis | Vessel | |
| ITGB1 | Integrin Subunit Beta 1 | Multiple myeloma; myocardial infarction; cardiomyopathy, dilated; heart failure; cardiomyopathies | Vessel | |
| NDUFAB1 | NADH: Ubiquinone Oxidoreductase Subunit AB1 | Hypertensive disease; coronary artery disease | Vessel | |
| NDUFS7 | NADH:Ubiquinone Oxidoreductase Core Subunit S7 | Cardiomyopathies | Vessel | |
| NDUFV1 | NADH:Ubiquinone Oxidoreductase Core Subunit V1 | Hypertrophic cardiomyopathy | Vessel | |
| PPP2R1A | Protein Phosphatase 2 Scaffold Subunit Alpha | Heart failure; congestive heart failure | Vessel | |
| RPL11 | Ribosomal Protein L11 | Conduction disorder of the heart; electrocardiogram abnormal; electrocardiogram change; EKG abnormalities; cardiac conduction abnormalities | Vessel | |
| SDHA | Succinate Dehydrogenase Complex Flavoprotein Subunit A | Hypertrophic cardiomyopathy; left ventricular noncompaction; gastrointestinal hemorrhage; cardiomyopathy, dilated, 1GG; cardiomyopathy, dilated | Vessel | |
| TUBA1A | Tubulin Alpha 1A | Myocardial ischemia | Vessel | |
| TXNRD2 | Thioredoxin Reductase 2 | Cardiomyopathy, dilated; myocardial infarction; cardiomyopathy, familial idiopathic; diabetic retinopathy; cerebrovascular accident | Vessel | |
| ACAA1 | Acetyl‐CoA Acyltransferase 1 | Carotid atherosclerosis | Valves | |
| ACAD9 | Acyl‐CoA Dehydrogenase Family Member 9 | Cardiomyopathy, dilated; hypertrophic cardiomyopathy; heart failure; congestive heart failure; cerebrovascular accident | Valves | |
| ALDH9A1 | Aldehyde Dehydrogenase 9 Family Member A1 | Hypertensive disease | Valves | |
| C1S | Complement C1s | Hereditary angioedema types I and II | Valves | |
| CAPZB | Capping Actin Protein of Muscle Z‐line Beta Subunit | Acute coronary syndrome | Valves | |
| CCT7 | Chaperonin Containing TCP1 Subunit 7 | Myocardial infarction | Valves | |
| COPS5 | COP9 Signalosome Subunit 5 | Arteriosclerosis; atherosclerosis | Valves | |
| DENR | Density Regulated RE‐1initiation and Release Factor | Heart failure; congestive heart failure; brain infarction; idiopathic pulmonary arterial hypertension | Valves | |
| EIF2S2 | Eukaryotic Translation Initiation Factor 2 Subunit Beta | Multiple myeloma | Valves | |
| EIF3E | Eukaryotic Translation Initiation Factor 3 Subunit E | Brain ischemia; intermittent claudication | Valves | |
| FLNA | Filamin A | Heart valve disease; mitral valve prolapse syndrome; aortic valve insufficiency; heart failure; congestive heart failure | Valves | |
| TPM3 | Tropomyosin 3 | Conduction disorder of the heart; electrocardiogram abnormal; electrocardiogram change; EKG abnormalities; cardiac conduction abnormalities | Valves | |
| FXN | Frataxin | Cardiomyopathies; hypertrophic cardiomyopathy; heart failure; congestive heart failure; echocardiogram abnormal | Valves | |
| HADHB | Hydroxyacyl‐CoA Dehydrogenasebeta Subunit | Cardiomyopathy, dilated; heart diseases; heart failure; congestive heart failure; cardiomyopathy, hypertrophic, familial | Valves | |
| HSP90B1 | Heat Shock Protein 90 Beta Family Member 1 | Multiple myeloma; cerebrovascular disorders; atrial fibrillation; chronic atrial fibrillation | Valves | |
| KIF5B | Kinesin Family Member 5B | Henoch‐Schoenlein purpura | Valves | |
| LONP1 | Lon Peptidase 1, Mitochondrial | Endocardial cushion defects; atrial septal defects; ventricular septal defects; atrioventricular canal defect; heart failure | Valves | |
| MYH11 | Myosin Heavy Chain 11 | Heart failure; congestive heart failure | Valves | |
| NDUFS3 | NADH:Ubiquinone Oxidoreductase Core Subunit S3 | Cardiomyopathy, familial Idiopathic hypertrophic, 3 (disorder); cardiomyopathy, dilated, 1y; hypertrophic cardiomyopathy; cardiomyopathy, dilated; cardiomyopathy, hypertrophic, familial | Valves | |
| PFKL | Phosphofructokinase, Liver Type | Cardiomyopathy, dilated; hypertrophic cardiomyopathy | Valves | |
| PSMC5 | Proteasome 26S Subunit, ATPase 5 | Patent ductus arteriosus; hypertensive disease; aortic valve insufficiency; left‐sided heart failure; coronary artery disease | Valves | |
| RPL11 | Ribosomal Protein L11 | Hypertrophic cardiomyopathy | Valves | |
| SPTBN1 | Spectrin Beta, Non‐erythrocytic 1 | Ventricular septal defects; tetralogy of fallot | Valves | |
| TPM1 | Tropomyosin 1 (alpha) | Arteriosclerosis; atherosclerosis | Valves | |
| TPM3 | Tropomyosin 3 | Conduction disorder of the heart; electrocardiogram abnormal; electrocardiogram change; EKG abnormalities; cardiac conduction abnormalities | Valves | |
| ACADVL | Acyl‐CoA Dehydrogenase, Very Long Chain | Hypertrophic cardiomyopathy; cardiac arrest; cardiomyopathies; sudden cardiac death | Cavities | |
| ACSS1 | Acyl‐CoA Synthetase Short‐chain Family Member 1 | Cerebrovascular accident; subarachnoid hemorrhage; intracranial hemorrhages; cerebral hemorrhage | Cavities | |
| AK1 | Adenylate Kinase 1 | Myocardial ischemia; myocardial infarction; infarction, middle cerebral artery | Cavities | |
| ALDOA | Aldolase, FructosE‐1bisphosphate A | Myocardial ischemia | Cavities | |
| CMPK1 | Cytidine/Uridine Monophosphate Kinase 1 | Kartagener syndrome | Cavities | |
| DLD | Dihydrolipoamide Dehydrogenase | Hypertrophic cardiomyopathy; hypertensive disease; atrial fibrillation; atrial premature complexes | Cavities | |
| EIF4E | Eukaryotic Translation Initiation Factor 4E | Multiple myeloma; myocardial ischemia; dementia, vascular | Cavities | |
| EIF4H | Eukaryotic Translation Initiation Factor 4H | Williams syndrome; hypertensive disease; coronary artery disease | Cavities | |
| GAPDH | GlyceraldehydE‐13‐phosphate Dehydrogenase | Bacterial endocarditis; ischemic cardiomyopathy; multiple myeloma; cardiomyopathy, familial idiopathic; acute coronary syndrome | Cavities | |
| HADHA | Hydroxyacyl‐CoA Dehydrogenase, Alpha Subunit | Congestive heart failure; myocardial ischemia; cardiomyopathy, hypertrophic, familial; cardiomyopathy, dilated; cardiomyopathies | Cavities | |
| HK1 | Hexokinase 1 | Myocardial ischemia; pulmonary hypertension | Cavities | |
| HRG | Histidine Rich Glycoprotein | Thrombosis; myocardial infarction | Cavities | |
| IDH1 | Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic | Venous thrombosis; vascular neoplasms; hemangioma; hemangiomatosis; visceral angiomatosis | Cavities | |
| PDK2 | Pyruvate Dehydrogenase Kinase 2 | Cardiomyopathies | Cavities | |
| PSMB1 | Proteasome Subunit Beta 1 | Acute coronary syndrome | Cavities | |
| RPL28 | Ribosomal Protein L28 | Infarction, middle cerebral artery | Cavities | |
| RPS2 | Ribosomal Protein S2 | Turner syndrome; Gonadal Dysgenesis, 45,X | Cavities | |
| RPS9 | Ribosomal Protein S9 | Takayasu arteritis | Cavities | |
| TSFM | Ts Translation Elongation Factor, Mitochondrial | Cardiomyopathies; patent ductus arteriosus; foramen ovale, patent; cardiomyopathy, concentric hypertrophic | Cavities | |
| TXNRD2 | Thioredoxin Reductase 2 | Cardiomyopathy, dilated; myocardial infarction; cardiomyopathy, familial idiopathic; diabetic retinopathy; cerebrovascular accident | Cavities | |
| VAMP3 | Vesicle Associated Membrane Protein 3 | Coronary artery disease | Cavities |
*
The region‐specific genes of monkey heart enriched in protein–protein interactions above were imported to a gene‐disease association analysis.
**
These genes associated with heart diseases were listed and involved in one or more cardiac‐related illnesses.
***
We only displayed the five major heart‐related disorders for one gene when exceeding this limit.
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