Table 3.
Statistical analyses of the oligoadenylate synthetase (OAS) gene exon 7 splice acceptor site (SAS) genotypes & alleles in non‐responder (NR) and sustained virological responder (SVR) patients
| Non responders (NR = 39) | Responders (SVR = 31) | Odds ratio | 95% confidence intervals | P‐value | |
|---|---|---|---|---|---|
| AA (n = 9) | 8 (20.51%) | 1 (3.23%) | 8.000 | 1.001–63.963 | 0.05 |
| AG (n = 29) | 18 (46.15%) | 11 (35.48%) | 1.636 | 0.773–3.465 | 0.198 |
| GG (n = 32) | 13 (33.33%) | 19 (61.29%) | 0.684 | 0.338–1.385 | 0.292 |
| A (n = 47) | 34 (72.34%) | 13 (27.66%) | 2.615 | 1.380–4.956 | 0.003 |
| G (n = 93) | 44 (47.31%) | 49 (52.69%) | 0.898 | 0.598–1.349 | 0.604 |
P‐values > 0.05 = Not significant; P‐values ≤ 0.05 = Significant.
Frequencies of genotypes and alleles at exon 7 SAS were compared between SVR and NR patients (columns 1 and 2). Odds ratio, confidence intervals and P‐value were represented in columns 3, 4 and 5. Genotype AA represents the lowest frequency among the studied sample of patients where it is mostly associated with NR (odds ratio = 8.00).
Data are expressed as number (%).