Table 1.
Categorisation of diagnostic parameters as consistent, doubtful and not consistent with FIP
Consistent (C) | Doubtful (D) | Not consistent (NC) | |
---|---|---|---|
History | Cattery with previous cases of FIP or high prevalence of positive serology | — | Households or pet cats without contacts with potential shedders of FCoV |
Clinical signs | Fever, effusion, ocular lesions, jaundice, masses, neurological signs | Masses, fever or neurological signs | None of the findings reported for group C or D |
Effusion | Macroscopic and cytological pattern consistent with FIP, high protein content, low A/G | Only some of the changes reported for group C | Macroscopic and cytological pattern not consistent with FIP, low protein content, normal A/G |
SPE | Hyperproteinemia, increased α2‐ and γ‐globulin, low A/G ratio | One or few electrophoretic abnormalities | Normal electrophoretic pattern |
AGP | >1·5 (mg/mL) | 0·5 to 1·5 (mg/mL) | <0·5 (mg/mL) |
Serology and/or PCR | Positive serology and/or PCR in blood and/or effusions | Positive serology and negative PCR (or vice versa) | Negative serology and/or PCR in blood and/or effusions |
Postmortem examination and/or histology | Fibrinous serositis and/or nodular lesions in one or more organs, histology consistent with fibrinous serositis and/or pyogranulomatous foci | Lesions as in group C but atypical localisation or presence of additional potential pathogens (e.g. fungi and bacteria) | Absence of lesions described in group C; presence of lesions consistent with diseases other than FIP (e.g. fibrosis) |
SPE serum protein electrophoresis, AGP α1‐acid glycoprotein