Table 1.
Validated targets of miR‐223
| Gene | Disease | Pathway | Cell type | Species | Reference |
|---|---|---|---|---|---|
| Artemin | Oesophageal carcinoma | Invasion/metastasis | Oesophageal cancer cell lines | H | 71 |
| C/EBPβ | Leukaemia | Differentiation/proliferation | Erythromyeloblast | H | 22 |
| E2F1 | AML | Cell cycle | AML blast | H | 55 |
| EPB41L3 | Gastric cancer | Metastasis | Cancer cell | H | 70 |
| Fbxw7/Cdc4 | Leukaemia, gastric cancer, oesophageal squamous cell carcinoma | Cell cycle regulation, proliferation | Erythroblast, gastric cancer cell, oesophageal squamous cell carcinoma | H, M | 56, 77, 78 |
| FOXO1 | Cancer | Proliferation | Cancer cell lines | H | 67 |
| Gag‐pol | HIV infection | HIV latency | CD4+ T cell | H | 51 |
| Granzyme B | Inflammation | NK cell activation | NK cell | M | 37 |
| HSP90B1 | Cancer | Cell survival | Osteosarcoma cell line | H | 66 |
| IGF1R | Inflammation, cancer | Neutrophil activation, eosinophil differentiation, cell survival/proliferation | Neutrophil, eosinophil, cancer cell lines, T‐ALL cell | H, M | 24, 33, 65 |
| IKKα | Inflammation | NF‐κB | Monocytes | H | 29 |
| LMO2 | Leukaemia/lymphoma | Erythroid and megakaryocyte differentiation | Megakaryocyte–erythroid progenitor | H | 22, 31, 32 |
| Mef2c | Granulocytosis, tumour immunology | Granulocyte progenitor proliferation, myeloid‐derived suppressor cell differentiation | Granulocyte progenitor, myeloid progenitor | M | 24, 74 |
| NFI‐A | Leukaemia/lymphoma | Myeloid differentiation | Myeloid progenitor | H | 20 |
| NFI‐A promoter | Leukaemia/lymphoma | Granulopoiesis, epigenetic silencing | Myeloid progenitor | H | 23 |
| NLRP3 | Inflammation | NLRP3 inflammasome | Monocyte/macrophage | H, M | 30, 35 |
| Pknox1 | Adipose tissue inflammation | Macrophage polarization | Macrophage | M | 34 |
| Rasa1 | Cancer | Cell cycle regulation | HeLa cell | H | 65 |
| RHOB | Cancer | Cytoskeleton remodelling/motility | Cancer cell lines | H | 79 |
| Roquin | Inflammation | IL‐17A production | Th17 cell | M | 43 |
| STAT3 | Inflammation | NF‐κB | Macrophage | M | 36 |
| STMN1 | HCC | Microtubule dynamics | Hepatocyte | H | 68 |
H, human; M, mouse.
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