Table 3.

Properties contributing to the relative risk of adenoviral vectors compared to wild‐type human adenovirus type 5 (HAdV5)

Properties	Example	Reference	Relative risk
Rep. comp. wt*	HAdV‐5	138	++
Rep. def.	HAdV‐5 dl312	139	+
Rep. def. + transgene	HAdV‐5 HSVtk	140	++
Rep. def. + host‐range restriction + transgene	HAdV‐5‐HSVtk‐CAR ablated	141	+
Rep. def. + host‐range expansion + transgene	HAdV‐5‐HSVtk‐RGD	142	+++
Rep. comp. + host‐range restriction	ONYX‐015	143	+
Rep. comp. + host‐range restriction + transgene	ONYX‐tk	144	++
Rep. comp. + host‐range expansion	CRAd‐RGD	145	+++
Rep. comp. + host‐range expansion + transgene	CRAd‐HSVtk‐RGD	145	++++

^*point of reference.

Abbreviations: rep. comp., replication‐competent; rep. def., replication‐deficient; wt, wild‐type; HAdV, human adenovirus; dl312, HAdV‐E1A‐deleted; HSVtk, thymidine kinase herpes simplex virus; CAR, coxsackievirus‐adenovirus receptor; RGD, arg‐gly‐asp tripeptide motif; CRAd, conditionally replicating adenovirus; ONYX‐015, HAdV‐E1B‐55kD‐deleted CRAd.

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