Figure 1.

mRNA decay model in innate immune response to endotoxin. LPS initiates a signaling cascade in macrophages, which engages transcriptional induction such as NF‐κB‐mediated gene expression and post‐transcriptional mechanisms, involving activation of the p38 MAPK, central in mRNA stabilization of many of the proinflammatory cytokines. This pathway affects the activity and subcellular localization of several RNA‐binding proteins such as TTP, which promote mRNA decay. Details are given in the text. MKK3/6, MAPK kinases 3/6.