Table IV.
Clinical Characteristics, Laboratory Findings, and Patient Management of Non‐Immunocompromised Patients Where Data was Available
| Total (n = 135) | Adenovirus (n = 42) | Astrovirus (n = 10) | Norovirus GII (n = 57) | Rotavirus (n = 26) | P‐value * | |
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Sex (male) | 64 (51.2) | 23 (54.8) | 4 (40.0) | 3 (53.1) | 10 (38.5) | 0.34 |
| Age (years)a | 1.46 (0.58–5.2) | 1.24 (0.51–4.9) | 0.97 (0.08–5.0) | 1.74 (0.58–5.2) | 1.04 (0.61–6.8) | 0.91 |
| Underlying medical condition | 56 (44.8) | 17 (40.5) | 3 (30.0) | 29 (50.9) | 10 (38.5) | 0.45 |
| Known sick contacts | 22 (17.6) | 8 (19.0) | 2 (20.0) | 11 (19.3) | 3 (11.5) | 0.66 |
| History and Physical Exam | ||||||
| Duration of symptoms (days)a | 6 (3–13) | 7 (4–20) | 6 (4–17) | 5 (3–16) | 6 (3–11) | 0.77 |
| Diarrhea | 121 (89.6) | 40 (95.2) | 8 (80.0) | 49 (86.0) | 24 (92.3) | 0.28 |
| Blood visible in stool | 36 (26.7) | 13 (31.0) | 3 (30.0) | 15 (26.3) | 5 (19.2) | 0.56 |
| Mucous visible in stool | 19 (15.2) | 6 (14.3) | 1 (10.0) | 10 (17.5) | 3 (11.5) | 0.76 |
| Duration of diarrhea (days)a | 6 (3–14) | 6 (0.5–12) | 9 (1.5–49) | 5 (3–16) | 7 (4–13) | 0.30 |
| Max no. of stools per daya | 6 (4–10) | 6 (4–12) | 5 (3–7) | 6 (4–10) | 7 (4–10) | 0.91 |
| Emesis | 70 (56.0) | 24 (57.1) | 7 (70.0) | 30 (52.6) | 16 (61.5) | 0.74 |
| Duration of emesis (days)a | 4 (2–6) | 4 (2.5–7) | 4 (3–6) | 2 (2–5) | 6 (4–8) | 0.10 |
| Max no. of emesis per daya | 3 (2–5) | 3 (2–4) | 5 (1–6) | 3 (2–5) | 4 (3–6) | 0.52 |
| Fever (> 38.3 °C) | 52 (41.6) | 18 (42.9) | 5 (50.0) | 24 (42.1) | 10 (38.5) | 0.93 |
| Abdominal cramping | 15 (12.0) | 4 (9.52) | 2 (20.0) | 8 (14.0) | 3 (11.5) | 0.79 |
| Abdominal distention | 23 (18.4) | 7 (16.7) | 0 (0.0) | 13 (22.8) | 3 (11.5) | 0.44 |
| Abdominal tenderness | 20 (16.0) | 7 (16.7) | 1 (10.0) | 12 (21.0) | 1 (3.9) | 0.14 |
| Lethargic | 41 (32.8) | 12 (28.6) | 2 (20.0) | 21 (36.8) | 8 (30.8) | 0.67 |
| Decreased oral intake prior to testing | 65 (52.0) | 22 (52.4) | 6 (60.0) | 29 (50.9) | 14 (53.9) | 0.97 |
| Decreased urine output | 21 (16.8) | 12 (28.6) | 1 (10.0) | 7 (12.3) | 2 (7.7) | 0.038 |
| Hypotension (out of normal range for age) | 8 (6.4) | 3 (7.1) | 1 (10.0) | 3 (5.3) | 2 (7.7) | 0.89 |
| Tachycardia | 37 (29.6) | 14 (33.3) | 1 (10.0) | 18 (28.1) | 11 (24.4) | 0.80 |
| Stool studies | ||||||
| Red blood cells present | 29 (23.2) | 11 (26.2) | 2 (20.0) | 14 (24.6) | 4 (15.4) | 0.56 |
| White blood cells present | 32 (25.6) | 12 (28.6) | 1 (10.0) | 17 (29.8) | 3 (11.5) | 0.18 |
| Bacterial culture positive | 7 (5.6) | 3 (7.1) | 0 (0.0) | 4 (7.0) | 0 (0.0) | 0.38 |
| Positive for C. difficile | 6 (4.8) | 0 (0.0) | 0 (0.0) | 4 (7.0) | 2 (7.7) | 0.20 |
| Management | ||||||
| Received IV fluids | 32 (25.6) | 11 (26.2) | 3 (30.0) | 13 (22.8) | 8 (31.0) | 0.74 |
| Admitted to hospital | 79 (63.2) | 27 (64.3) | 6 (60.0) | 34 (59.7) | 18 (69.2) | 0.85 |
| Admitted for GI reasons | 60 (48.0) | 21 (50.0) | 6 (60.0) | 26 (45.6) | 13 (50.0) | 0.89 |
| Admitted to pediatric ICU | 17 (13.6) | 4 (9.5) | 1 (10.0) | 9 (15.8) | 4 (15.4) | 0.64 |
| Length of stay (days)a | 8 (4–15) | 7 (4–20) | 4 (3–6) | 9 (5–15) | 11 (4–23) | 0.48 |
a
indicates median number and interquartile range.
*
statistical analysis performed on adenovirus, rotatvirus, and norovirus GII samples as clinical data was available on sufficient number of patients.