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. 2015 Feb 2;98(1):5–14. doi: 10.1189/jlb.4HI0714-338RR

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© 2015 Society for Leukocyte Biology

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Impact of cytokine stimulation on SAMHD1 expression and phosphorylation in MDMs. Immunoblot analysis of MDM after 24 h of treatment with indicated concentrations of different cytokines (ng/ml for IL‐12/IL‐18/TNF‐α and IU/ml for IFN‐α/IFN‐γ). Cells were lysed and analyzed with anti‐pSAMHD1(T592)) and anti‐pan‐SAMHD1 antibodies. Activated CD4⁺ T cells served as positive control for pSAMHD1(T592) detection. MxA served as a positive control for IFN‐induced gene expression and MAPK as a loading control. Shown is 1 representative donor out of 7.