Table 3.

WSAVA Feline Vaccination Guidelines

Vaccine	Initial kitten vaccination (≤ 16 weeks)	Initial adult vaccination (> 16 weeks)	Revaccination recommendation	Comments
Panleukopenia Virus (FPV; MLV, parenteral)	Begin at 8–9 weeks of age, with second dose 3–4 weeks later, and final dose at 16 weeks of age or later	2 doses, 3–4 weeks apart	A single dose is given 1 year following the last dose of the initial series, then no more frequently than every 3 years	Core. Use of MLV vaccines is not recommended in pregnant cats and FeLV and/or FIV infected cats. Intranasal vaccination may not be as effective as injectable vaccination in high‐risk environments where exposure may occur soon after vaccination such as animal shelters. Parenteral MLV is recommended in shelters.
FPV (killed, adjuvanted or killed, non‐adjuvanted, parenteral)
FPV (MLV, non‐adjuvanted, intranasal)
Feline Herpesvirus‐1 (FHV‐1; MLV, non‐adjuvanted, parenteral and intranasal products are available)	Begin at 8–9 weeks of age, with second dose 3–4 weeks later, and final dose at 16 weeks of age or later.	2 doses, 3–4 weeks apart	A single dose is given 1 year following the last dose of the initial series, then every 3 years.	Core. MLV FHV‐1/FCV vaccines are invariably combined with each other, either as bivalent products or in combination with additional vaccine antigens (e.g. FPV). Mild upper respiratory disease signs are occasionally seen following intranasal vaccination.
FHV‐1 (killed, adjuvanted, parenteral)
Feline calicivirus (FCV; MLV, non‐adjuvanted, parenteral and intranasal products are available)	Begin at 8–9 weeks of age, with second dose 3–4 weeks later, and final dose at 16 weeks of age or later.	2 doses, 3–4 weeks apart	A single dose is given 1 year following the last dose of the initial series, then every 3 years.	Core. MLV FHV‐1/FCV vaccines are invariably combined with each other, either as bivalent products or in combination with additional vaccine antigens. Mild upper respiratory disease signs are occasionally seen following intranasal vaccination.
FCV (killed, adjuvanted, parenteral)
Rabies (canary pox virus‐vectored recombinant, non‐adjuvanted, parenteral)	Administer a single dose as early as 8 weeks of age, with revaccination 1 year later.	Administer 2 doses, 12 months apart.	Annual booster is required.	Non‐core except where required by statute (e.g. for pet travel) or in areas where the disease is endemic
Rabies (1, 3 and 4 year killed, adjuvanted products are available, parenteral)	Administer a single dose as early as 12 weeks of age, with revaccination 1 year later.	Administer 2 doses, 12 months apart.	Booster as per licensed DOI or as required by local regulations.	Non‐core except where required by statute (e.g. for pet travel) or in areas where the disease is endemic
Feline Leukemia Virus (FeLV; canary pox virus‐vectored recombinant, non‐adjuvanted, transdermal USA and injectable elsewhere)	Administer an initial dose as early as 8 weeks of age; a second dose should be administered 3–4 weeks later. Two initial doses required.	2 doses, 3–4 weeks apart	When indicated a single dose is given 1 year following the last dose of the initial series, then not more often than every 3 years in cats determined to have sustained risk of exposure.	Non‐Core. In the United States, the 0.25 ml rFeLV vaccine dose may only be administered via the manufacturer’s transdermal administration system. Only FeLV negative cats should be vaccinated. FeLV testing prior to vaccine administration should be mandatory.
FeLV (killed, adjuvanted, parenteral)	Administer an initial dose as early as 8 weeks of age; a second dose should be administered 3–4 weeks later. Two initial doses required.	2 doses, 3–4 weeks apart	When indicated, a single dose is given 1 year following the last dose of the initial series, then not more often than every 3 years in cats determined to have sustained risk of exposure.	Non‐Core. Only FeLV negative cats should be vaccinated. FeLV testing prior to vaccine administration should be mandatory.
FeLV (recombinant protein subunit, adjuvanted, parenteral)
Feline Immunodeficiency Virus (FIV; killed, adjuvanted, parenteral)	3 doses are required:	3 doses are required:	When indicated, a single dose is given 1 year following the last dose of the initial series, then annually in cats determined to have sustained risk of exposure.	Not recommended. Vaccination induces production of antibodies indistinguishable from those developed in response to FIV infection, and interferes with antibody‐based FIV diagnostic tests for at least a year following vaccination. Some discriminatory serological tests have been reported and quantitative PCR diagnostics are becoming more widely available.
	The initial dose is administered as early as 8 weeks of age; 2 subsequent doses should be administered at an interval of 2–3 weeks.	Each dose is administered 2 –3 weeks apart.
Feline Infectious Peritonitis (FIP; MLV, non‐adjuvanted, intranasal)	Administer a single dose as early as 16 weeks of age, and a second dose 3–4 weeks later.	2 doses, 3–4 weeks apart.	Annual booster is recommended by the manufacturer.	Not Recommended. According to the limited studies available, only cats known to be feline coronavirus antibody negative at the time of vaccination are likely to develop some level of protection. It is rare that a cat will be coronavirus antibody negative.
Chlamydophila felis (avirulent live, non‐adjuvanted, parenteral)	Administer the initial dose as early as 9 weeks of age; a second dose is administered 3–4 weeks later.	Administer 2 doses, 3–4 weeks apart.	Annual booster is indicated for cats with sustained exposure risk.	Non‐Core. Vaccination is most appropriately used as part of a control regime for cats in multiple‐cats environments where infections associated with clinical disease have been confirmed. Inadvertent conjunctival inoculation of vaccine has been reported to cause clinical signs of infection. These vaccines may be associated with adverse reactions (hypersensitivity).
Chlamydophila felis (killed, adjuvanted, parenteral)
Bordetella bronchiseptica (avirulent live, non‐adjuvanted, intranasal)	Administer a single dose intranasally as early as 8 weeks of age.	Administer a single dose intranasally	Annual booster is indicated for cats with sustained risk.	Non‐Core. Vaccination may be considered in cases where cats are likely to be at specific risk of infection. Studies have not shown this product to reduce severity of the feline respiratory disease complex.

The killed parenteral Giardia lamblia vaccine for the cat (listed in the 2007 guidelines) is now no longer available.