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. 2016 Aug 22;89(3):542–545. doi: 10.1002/jmv.24652

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© 2016 Wiley Periodicals, Inc.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Schematic representation of MERS‐CoV spike gene coding region and predicted protein(s): SP, signal peptide; NTD, N‐terminal domain; RBD, receptor‐binding domain; FP, fusion peptide; IFP, internal fusion peptide; HR1, heptad repeat 1; HR2, heptad repeat 2; TM, transmembrane domain; CP, cytoplasmic domain (modified from Gao et al. [2013]). Panel A. MERS‐CoV spike gene amplicons generated by primer pair SF6/SR6 from serum of select Taif outbreak case‐patients (1). Lane designations: M, molecular weight marker; #, case‐patient identification numbers; −, negative template control; +, positive template control. Panel B. Wild‐type and variant spike gene with 530 nucleotide frame‐shift deletion mutation obtained from patient #27. Panel C. Wild‐type and truncated precursor proteins predicted for these genes. Stop codon (*).