Table II.
Comparison of the Median Value of the HBoV DNA Viral Load in Children With a Single HBoV Infection and Children With HBoV Coinfection
| Characteristics | Median viral load in children with HBoV infection (copies/ml) | P‐value | |
|---|---|---|---|
| HBoV single infection (n = 66) | HBoV coinfection (n = 98) | ||
| Demographic data | |||
| Gender | |||
| Female | 1.8 × 107 (n = 24) | 1.0 × 104 (n = 39) | 0.005 |
| Male | 5.4 × 105 (n = 42) | 4.3 × 104 (n = 59) | 0.293 |
| Age groups | |||
| 0–12 months | 2.6 × 104 (n = 16) | 2.3 × 104 (n = 24) | |
| 24 months | 4.1 × 107 (n = 35) | 1.8 × 106 (n = 54) | 0.005 |
| ≥25 months | 1.9 × 104 (n = 15) | 1.1 × 104 (n = 20) | |
| Underlying disease | |||
| Prematurity, congenital immunodeficiency, or other congenital (pulmonary, cardiac) disorders | 4.1 × 107 (n = 14) | 1.2 × 104 (n = 19) | 0.001 |
| Laboratory findings | |||
| CRP <8 mg/L | 5.2 × 106 (n = 25) | 1.4 × 104 (n = 46) | 0.001 |
| WBC >10 × 109 cells/ml | 7.4 × 105 (n = 54) | 4.3 × 104 (n = 65) | 0.033 |
| Hypoxia (sat. O2 <94%) | 5.3 × 105 (n = 53) | 3.2 × 104 (n = 80) | 0.044 |
| Final diagnosis | |||
| Upper respiratory tract infection | 1.8 × 104 (n = 2) | 6.0 × 107 (n = 2) | 0.121 |
| Lower respiratory tract infection | 8.9 × 105 (n = 64) | 2.5 × 104 (n = 96) | 0.003 |
| Pneumonia | 2.2 × 107 (n = 16) | 1.3 × 104 (n = 14) | 0.096 |
| Bronchiolitis | 7.2 × 105 (n = 42) | 3.4 × 104 (n = 71) | 0.044 |
| Bronchitis | 0 | 2.3 × 105 (n = 1) | ND |
| Recurrent wheezing | 8.6 × 104 (n = 6) | 1.9 × 104 (n = 7) | 0.391 |
| Asthma | 0 | 3.5 × 103 (n = 3) | ND |
HBoV, human bocavirus; CRP, C‐reactive protein; WBC, white blood cells; ND, not done.
P‐values <0.05 are significant. Statistical values are in bold.