Figure 3.

3D structures of solved HCV NS5b polymerase (PDB ID 2XI3) with GTP and the docked GTP to MERS CoV selected model. Polar interactions occur in both cases with the active site amino acids (Asp318 for HCV & Asp255 and Asp256 for MERS CoV) and the active site pocket amino acids. In addition, metal interactions mediate ligand binding to the polymerases. Structures are presented using PyMOL software where proteins are represented by colored cartoon and the drugs are represented by atom colored licorice (N, blue; O, red; C, green; H, white; and P, orange)