Table 2.
Noncompartmental pharmacokinetic parameters for trazodone following administration of 7.5 or 10 mg/kg orally to six horses
| Pharmacokinetic Variable | 7.5 mg/kg Mean ± SD | 10 mg/kg Mean ± SD |
|---|---|---|
| T max (hr) | 0.37 ± 0.20 | 0.42 ± 0.09 |
| C max (μg/ml) | 2.45 ± 0.79 | 4.07 ± 2.23 |
| AUC0–∞ (μg*hr/ml)a | 5.77 ± 1.929 | 11.42 ± 7.30 |
| AUC0–∞ (% extrap) | 1.20 ± 0.73 | 1.21 ± 1.63 |
| AUMC (hr*hr*μg/ml) | 35.09 ± 27.96 | 86.39 ± 70.23 |
| λ (hr−1) | 0.093 ± 0.025b | 0.10 ± 0.02 |
| t 1/2λ (hr) | 7.86 ± 1.76b | 7.19 ± 1.84 |
T max, time to maximum concentration; C max, maximum concentration; AUC, area under the concentration–time curve; AUMC, area under the first moment–time curve; λ, slope of the terminal phase; t 1/2λ, half‐life of terminal phase.
Statistical difference detected between value for 7.5 and 10 mg/kg dose (p = .0482).
Indicates data from five horses only.
This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.