Table 3.
Noncompartmental pharmacokinetic parameters for m‐CPP following administration of 7.5 or 10 mg/kg trazodone orally to six horses
| Pharmacokinetic Variable | 7.5 mg/kg Mean ± SD | 10 mg/kg Mean ± SD |
|---|---|---|
| T max (hr) | 0.57 ± 0.26 | 0.53 ± 0.19 |
| C max (μg/ml) | 0.04 ± 0.03 | 0.07 ± 0.02 |
| AUC0–∞ (μg*hr/ml) | 0.13 ± 0.07 | 0.31 ± 0.20 |
| AUC0–∞ (% extrap) | 18.35 ± 7.19 | 18.52 ± 6.03 |
| AUMC (hr*hr*μg/ml) | 0.77 ± 0.57 | 5.52 ± 6.50 |
| λ (hr−1) | 0.21 ± 0.10 | 0.13 ± 0.08 |
| t 1/2λ (hr) | 3.95 ± 1.93 | 6.85 ± 3.64 |
T max, time to maximum concentration; C max, maximum concentration; AUC, area under the concentration–time curve; AUMC, area under the first moment–time curve; λ, slope of the terminal phase; t 1/2λ, half‐life of terminal phase.
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