Table II.
Factors Associated With the Disease Severity
| Mild bronchiolitis (n = 83) | Moderate bronchiolitis (n = 84) | Severe bronchiolitis (n = 55) | P‐value | |
|---|---|---|---|---|
| Male, n (%) | 49 (59) | 53 (63) | 29 (53) | 0.48 |
| Age (months) | ||||
| Mean, SD | 4.3 ± 2.8 | 3.9 ± 2.6 | 3.9 ± 3.1 | 0.33 |
| Familial history of atopy, n (%) | 31 (46) | 43 (57) | 26 (54) | 0.41 |
| Exposure to tobacco smoke, n (%) | 29 (49) | 42 (61) | 20 (47) | 0.25 |
| Personal history of atopy, n (%) | 27 (40) | 27 (36) | 14 (29) | 0.46 |
| No nursery care attendance, n (%) | 29 (49) | 37 (56) | 24 (59) | 0.60 |
| Serum KL‐6 level (IU/ml) | ||||
| Mean, SD | 223 ± 109 | 238 ± 102 | 236 ± 109 | 0.48 |
| Hospitalization, n (%) | 49 (59) | 68 (81) | 55 (100) | <0.001 |
| Length of stay (days) mean, SD | 4.2 ± 3.2 | 4.8 ± 3.6 | 5.9 ± 3.5 | 0.016 |
| Hospitalization in Pediatric Intensive Care Unit, n (%) | 0 (0) | 3 (4) | 8 (15) | <0.001 |
| Oxygen saturation (%) mean, SD | 98.3 ± 1.8 | 97.6 ± 2.1 | 95.1 ± 4.2 | <0.001 |
| Need for oxygen therapy, n (%) | 16 (19) | 28 (33) | 41 (75) | <0.001 |
| Duration of oxygen therapy (days) mean, SD | 0.7 ± 1.8 | 1.1 ± 1.9 | 2.2 ± 2 | <0.001 |
| Respiratory rate (min−1) mean, SD | 43.4 ± 9.6 | 46.9 ± 11.8 | 57.9 ± 16.6 | <0.001 |
| CRP (mg/ml)a mean, SD | 13.5 ± 18.4 | 12.4 ± 18.9 | 17.1 ± 30 | 0.77 |
| RSV only, n (%) | 36 (61) | 45 (70) | 30 (70) | 0.49 |
| RSV + other virus, n (%) | 23 (39) | 19 (30) | 13 (30) | |
| HRV only, n (%) | 9 (31) | 7 (26) | 6 (38) | 0.73 |
| HRV + other virus, n (%) | 20 (69) | 20 (74) | 10 (62) | |
| Need for gastroenteral feeding, n (%) | 19 (40) | 35 (52) | 35 (64) | 0.06 |
RSV, Respiratory syncytial virus; HRV, Human Rhinovirus.
a
Available from 104 patients.