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Identification of multidrug‐resistant (MDR) mutations. Clonal sequencing identified that eight patients who received sequential NA harboured MDR mutants with signature mutations resistant to both nucleoside (LAM/LdT/ETV) and nucleotide analogues (ADV). The NA treatment schedules are shown at the bottom of the figure. Treatment duration (month) is indicated in brackets. LAM, lamivudine; ADV, adefovir; ETV, entecavir; LdT, telbivudine; NA, nucleos(t)ide analogues.
