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Structure of M. tuberculosis MscL derived from X-ray crystallography. (A) MscL pentamer shown from a periplasmic view (left) and a side view (right) in which the approximate membrane location is indicated by gray lines. (B) A single isolated subunit is represented in which different MscL domains are indicated: N-terminal helix, called S1 helix (green), first transmembrane domain TM1 (blue), periplasmic loop (cyan), second transmembrane domain TM2 (red), and C-terminal helix (orange).
