Table 3.
Predicted Target Genes for Rno-miR-141-3p and Rno-miR-144-3p
| microRNA | Gene Symbol | Gene Name | Gene Function in Heart |
|---|---|---|---|
| rno-miR-141-3p | Thrb | Thyroid hormone receptor beta | Modulation of cardiac hypertrophy |
| Ppm1l | Protein phosphatase, Mg2+/Mn2+ dependent, 1L | Modulation of cardiac function | |
| Brd3 | Bromodomain containing 3 | Modulation of cardiac hypertrophy | |
| Peg3 | Paternally expressed 3 | Modulation of cardiac fibrosis | |
| Zeb1 | Zinc finger E-box binding homeobox 1 | Modulation of cardiac fibrosis | |
| Tiam1 | T-cell lymphoma invasion and metastasis 1 | Modulation of cardiac hypertrophy | |
| Rheb | Ras homolog, mTORC1 binding | Modulation of cardiac hypertrophy | |
| Ube3a | Ubiquitin protein ligase E3A | Modulation of cardiac hypertrophy | |
| Klf6 | Kruppel-like factor 6 | Modulation of cardiac fibrosis | |
| Pkn2 | Protein kinase N2 | Modulation of cardiac function, hypertrophy and fibrosis | |
| Grb2 | Growth factor receptor bound protein 2 | Modulation of cardiac fibrosis | |
| Cdk6 | Cyclin-dependent kinase 6 | Modulation of cardiac fibrosis | |
| Pou4f2 | POU class 4 homeobox 2 | Modulation of cardiac hypertrophy | |
| Ezh1 | Enhancer of zeste 1 polycomb repressive complex 2 subunit | Modulation of cardiac fibrosis | |
| Lmbrd1 | LMBR1 domain containing 1 | Modulation of cardiac hypertrophy | |
| Ppp2ca | Protein phosphatase 2 catalytic subunit alpha | Modulation of cardiac hypertrophy | |
| Pacsin2 | Protein kinase C and casein kinase substrate in neurons 2 | Modulation of cardiac function | |
| Pln | Phospholamban | Modulation of cardiac hypertrophy | |
| Gata6 | GATA binding protein 6 | Modulation of cardiac fibrosis | |
| rno-miR-144-3p | Herpud1 | Homocysteine inducible ER protein with ubiquitin like domain 1 | Modulation of cardiac hypertrophy |
| Smad4 | SMAD family member 4 | Modulation of cardiac fibrosis | |
| Hdac2 | Histone deacetylase 2 | Modulation of cardiac hypertrophy | |
| Zeb1 | Zinc finger E-box binding homeobox 1 | Modulation of cardiac fibrosis | |
| Aplp2 | Amyloid beta precursor like protein 2 | Modulation of cardiac hypertrophy | |
| Acsl4 | Acyl-CoA synthetase long-chain family member 4 | Modulation of cardiac hypertrophy | |
| Cxcl12 | C-X-C motif chemokine ligand 12 | Modulation of cardiac fibrosis | |
| Idh2 | Isocitrate dehydrogenase (NADP(+)) 2, mitochondrial | Modulation of cardiac hypertrophy | |
| Cyp2c11 | Cytochrome P450, subfamily 2, polypeptide 11 | Modulation of cardiac hypertrophy | |
| Mmp16 | Matrix metallopeptidase 16 | Modulation of cardiac fibrosis | |
| Ezh2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit | Modulation of hypertrophy and fibrosis | |
| Cav3 | Caveolin 3 | Modulation of cardiac hypertrophy | |
| Rock2 | Rho-associated coiled-coil containing protein kinase 2 | Modulation of cardiac function, hypertrophy and fibrosis | |
| Klf6 | Kruppel-like factor 6 | Modulation of cardiac fibrosis | |
| Mtor | Mechanistic target of rapamycin kinase | Modulation of hypertrophy and fibrosis | |
| Foxo1 | Forkhead box O1 | Modulation of hypertrophy and fibrosis | |
| Tlr2 | Toll-like receptor 2 | Modulation of cardiac fibrosis |