Table 1.
A summary of adhesion GPCR nomenclature and key signaling pathways
| Sub-group | New nomenclature | Previous identifier(s) | Signaling pathways | NTF interactors |
|---|---|---|---|---|
| III | ADGRA1 | GPR123 | ||
| ADGRA2 | GPR124, TEM5 | β-catenin (47), Cdc42 (99) | Heparin (71), αvβ3 Integrin (71), WNT7 (47) | |
| ADGRA3 | GPR125 | |||
| VII | ADGRB1 | BAI1 | Rac1 (45; 46), Gα12/13, RhoA (12; 19) | PtdSer (45), LPS (62), αvβ5 Integrin (63) |
| ADGRB2 | BAI2 | Gα16, NFAT-Luc (21) | ||
| ADGRB3 | BAI3 | C1ql1 (65), C1ql3 (64) | ||
| IV | ADGRC1 | CELSR1 | Rho kinase (51; 52) | |
| ADGRC2 | CELSR2 | Ca2+ (48) | C2 NTF (48) | |
| ADGRC3 | CELSR3 | Ca2+ (48) | C3 NTF (48) | |
| V | ADGRD1 | GPR133 | Gαs (161), cAMP (42; 161) | |
| ADGRD2 | GPR144 | |||
| II | ADGRE1 | EMR1 | ||
| ADGRE2 | EMR2 | Gα15 (42) | Chondroitin sulfate (68) | |
| ADGRE3 | EMR3 | |||
| ADGRE4 | EMR4 | |||
| ADGRE5 | CD97 | Gα12/13, RhoA (20) | CD55 (66; 67; 135), Chondroitin sulfate (68), Thy-1 (CD90) (69), α5β1 Integrin | |
| VI | ADGRF1 | GPR110 | Gαq (27), Gαs cAMP (34; 77) | Synaptamide (77) |
| ADGRF2 | GPR111 | |||
| ADGRF3 | GPR113 | |||
| ADGRF4 | GPR115 | Gα15 (42) | ||
| ADGRF5 | GPR116, Ig-Hepta | Gαq-RhoA/Rac1 (128) Gαq-IP1 (23) | Surfactant protein D (79) | |
| VIII | ADGRG1 | GPR56 | Gα12/13, RhoA (12; 18; 27; 37; 75), Gαq/11 (38) | Tissue transglutaminase (72; 73), Collagen III (74; 75) |
| ADGRG2 | GPR64, HE6 | cAMP (23; 24), MAPK, RhoA (14) | ||
| ADGRG3 | GPR97 | Gαo (42), RhoA and Cdc42 (43) | ||
| ADGRG4 | GPR112 | SRE-Luc (44) | ||
| ADGRG5 | GPR114 | Gαs (42) | ||
| ADGRG6 | GPR126 | cAMP (25; 26; 32; 39), | Collagen IV (25), Laminin-211 (32), Prion protein (76) | |
| ADGRG7 | GPR128 | |||
| I | ADGRL1 | LPHN1, CIRL, CL1 | Gαo (35; 36), Gαq (36) | α-latrotoxin (35; 54; 55), neurexins (56), teneurins (58), FLRT1 and 3 (57) |
| ADGRL2 | LPHN2, CIRL2, CL2 | teneurins (58), FLRT3 (57) | ||
| ADGRL3 | LPHN3, CIRL3, CL3 | teneurins (58), FLRT1 and 3(57), FLRT2 and Unc5 (60) | ||
| ADGRL4 | ELTD1 | |||
| IX | ADGRV1 | VLGR1, GPR98, MASS1 | Gαi (28), Gαs and Gαq (53) |