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. Author manuscript; available in PMC: 2020 Apr 19.
Published in final edited form as: Annu Rev Pharmacol Toxicol. 2017 Oct 2;58:429–449. doi: 10.1146/annurev-pharmtox-010617-052933

Table 1.

A summary of adhesion GPCR nomenclature and key signaling pathways

Sub-group New nomenclature Previous identifier(s) Signaling pathways NTF interactors
III ADGRA1 GPR123
ADGRA2 GPR124, TEM5 β-catenin (47), Cdc42 (99) Heparin (71), αvβ3 Integrin (71), WNT7 (47)
ADGRA3 GPR125
VII ADGRB1 BAI1 Rac1 (45; 46), Gα12/13, RhoA (12; 19) PtdSer (45), LPS (62), αvβ5 Integrin (63)
ADGRB2 BAI2 16, NFAT-Luc (21)
ADGRB3 BAI3 C1ql1 (65), C1ql3 (64)
IV ADGRC1 CELSR1 Rho kinase (51; 52)
ADGRC2 CELSR2 Ca2+ (48) C2 NTF (48)
ADGRC3 CELSR3 Ca2+ (48) C3 NTF (48)
V ADGRD1 GPR133 s (161), cAMP (42; 161)
ADGRD2 GPR144
II ADGRE1 EMR1
ADGRE2 EMR2 15 (42) Chondroitin sulfate (68)
ADGRE3 EMR3
ADGRE4 EMR4
ADGRE5 CD97 12/13, RhoA (20) CD55 (66; 67; 135), Chondroitin sulfate (68), Thy-1 (CD90) (69), α5β1 Integrin
VI ADGRF1 GPR110 q (27), Gαs cAMP (34; 77) Synaptamide (77)
ADGRF2 GPR111
ADGRF3 GPR113
ADGRF4 GPR115 15 (42)
ADGRF5 GPR116, Ig-Hepta q-RhoA/Rac1 (128) Gαq-IP1 (23) Surfactant protein D (79)
VIII ADGRG1 GPR56 12/13, RhoA (12; 18; 27; 37; 75), Gαq/11 (38) Tissue transglutaminase (72; 73), Collagen III (74; 75)
ADGRG2 GPR64, HE6 cAMP (23; 24), MAPK, RhoA (14)
ADGRG3 GPR97 o (42), RhoA and Cdc42 (43)
ADGRG4 GPR112 SRE-Luc (44)
ADGRG5 GPR114 s (42)
ADGRG6 GPR126 cAMP (25; 26; 32; 39), Collagen IV (25), Laminin-211 (32), Prion protein (76)
ADGRG7 GPR128
I ADGRL1 LPHN1, CIRL, CL1 o (35; 36), Gαq (36) α-latrotoxin (35; 54; 55), neurexins (56), teneurins (58), FLRT1 and 3 (57)
ADGRL2 LPHN2, CIRL2, CL2 teneurins (58), FLRT3 (57)
ADGRL3 LPHN3, CIRL3, CL3 teneurins (58), FLRT1 and 3(57), FLRT2 and Unc5 (60)
ADGRL4 ELTD1
IX ADGRV1 VLGR1, GPR98, MASS1 i (28), Gαs and Gαq (53)