FIG 8.

FtsA mediates CTL-dependent regulation of PG enzyme activity during division. (A) In wild-type cells, FtsZ (light blue) directs activity of PG enzymes (green) through FtsA (dark blue) and other divisome components (orange) via a mechanism requiring interaction between the FtsZ C terminus (CTC) and FtsA (yellow flash), resulting in constriction. (B) FtsZ lacking its C-terminal linker (ΔCTL) exhibits a higher degree of filament lateral interaction and has a disrupted interaction with FtsA (red flash), resulting in aberrant regulation of PG enzymes (dashed arrows) that culminates in bulging and lysis.