Table 1.
Comparison of clinical characteristics of patients with RT023 versus other ribotypes (excluding RT027 and RT078/126), RT027, RT078/126, RT014/020/295 and RT001
| RT023 (n = 141) | Primary outcome |
Hypervirulent strains |
Non-hypervirulent strains |
All info available | |||
|---|---|---|---|---|---|---|---|
| Others (n = 4368) | RT027 (n = 116) | RT078/126 (n = 734) | RT014/020/295 (n = 962) | RT001 (n = 699) | |||
| Age | 71.4 (10.0–97.7) | 71.3 (1.9–102.3) | 73.2 (11.2–91.5) | 70.9 (5.2–100.7) | 70.4 (2.1–99.2) | 76.0 [3.3, 96.7]* | 5359/5359 |
| Men | 71 (50) | 2095 (48) | 63 (54) | 365 (50) | 444 (46) | 344 (49) | 5356/5359 |
| Severe CDI | 45 (35) | 880 (22)* | 30 (29) | 188 (27) | 185 (21)* | 104 (16)* | 4948/5359 |
| Dehydration and/or hypoalbuminaemia | 25 (20) | 450 (11)* | 14 (14) | 100 (15) | 97 (11)* | 44 (7)* | 4940/5359 |
| Bloody diarrhoea | 10 (8) | 192 (5) | 6 (6) | 25 (4)* | 34 (4)* | 24 (4)* | 4948/5359 |
| Pseudomembranous colitis | 8 (6) | 159 (4) | 6 (6) | 41 (6) | 28 (3) | 21 (3) | 4948/5359 |
| Fever and leucocytosis | 11 (9) | 295 (7) | 9 (9) | 76 (11) | 64 (7) | 36 (6) | 4940/5359 |
| Complicated course | 13 (12) | 485 (14) | 21 (23)* | 104 (17) | 78 (10) | 95 (17) | 4387/5359 |
| Overall mortality | 10 (9) | 428 (12) | 18 (19)* | 98 (16)* | 68 (9) | 86 (15) | 4387/5359 |
| CDI mortality | 2 (2) | 104 (3) | 4 (4) | 29 (5) | 16 (2) | 27 (5) | 4387/5359 |
| Community onset | 75 (54) | 1545 (36)* | 31 (27)* | 272 (37)* | 356 (38)* | 155 (23)* | 5283/5359 |
| CDI last 8 weeks | 22 (27) | 684 (25) | 12 (20) | 133 (29) | 161 (27) | 115 (25) | 3312/5359 |
Abbreviations: CDI, Clostridium difficile infection; HCF, health-care facility; LTCF, long-term-care facility; RT, ribotype.
Data are presented as number of cases (percentage). Age is presented as median (first quartile, third quartile), because of the skewed distribution. Categorical variables were compared by a Pearson's chi-square test and numerical variables were compared by a Wilcoxon rank-sum test. An asterisk (*) represents a p < 0.05, when comparing with RT023.