. Author manuscript; available in PMC: 2020 Apr 20.

Published in final edited form as: Eur J Clin Pharmacol. 2015 Aug 2;71(10):1197–1207. doi: 10.1007/s00228-015-1913-0

Table 1.

Population pharmacokinetic parameters for dexmedetomidine

Parameter (unit)	Definition	Estimate		Inter-individual variability
V₁ (L)	Central volume	14.3	(20.5)	0.33 (38.6) [2]
CL (L/h)	Systemic clearance	44.0	(7.0)	0.058(41.3) [4]
V₂ (L)	Peripheral volume	75.0	(6.1)	0.021 (49.5) [8]
CL_D (L/h)	Inter-compartmental clearance	103	(5.1)	-
k_a (h⁻¹)	Absorption rate constant	0.94	(9.6)	-
F	Bioavailability	0.82	(5.4)	-
ALAG (h)	Lag time	0.0428	(17.1)	-
Residual variability
Proportional error		0.112	(6.3)

(%) RSE, [%] shrinkage