Table 2.
Pharmacodynamic parameters for dexmedetomidine effects on norepinephrine and epinephrine
Parameter (unit) | Definition | Estimate | |
---|---|---|---|
Norepinephrine | Epinephrine | ||
R0 (nmol/L) | Baseline | 9.48 (43.5)a | 0.22 (14.4) |
kd,s (h−1)a | Disposition rate constant | 10.2 (44.4)a | - |
IC50 (ng/mL) | Drug concentration at one-half maximal inhibition of response | 0.153 (38.2) | 0.166 (11.9) |
kd,p (h−1) | Disposition rate constant | 19.1 (82.2) | 3.67 (20.8) |
Inter-individual variability | |||
R0 (nmol/L) | - | 0.34 (37.6) [2] | |
IC50 | 0.3 (88.0) [7] | - | |
Residual variability | |||
Additive error (nmol/L) | 0.072 (39.8) | - | |
Proportional error | 0.356 (19.8) | 0.56 (11.5) |
(%) RSE, [%] shrinkage
In noradrenergic nerve