Skip to main content
. Author manuscript; available in PMC: 2020 Apr 20.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2018 Apr 27;45(4):557–575. doi: 10.1007/s10928-018-9585-x

Fig. 6.

Fig. 6

Hepatic TAT mRNA (left panel), TAT protein (center panel), and TAT activity (right panel) dynamics during a 0.3 mg/kg/h SC infusion of MPL for 7 days. Each circle is an individual measurement from one rat and solid lines depict simulated predictions performed based on the developed model (Fig. 1) using parameters shown in Tables 1 and 2. Data were from a previous report. Reproduced with Permission from Ramakrishnan et al. [35]