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. Author manuscript; available in PMC: 2020 Apr 20.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2018 Apr 27;45(4):557–575. doi: 10.1007/s10928-018-9585-x

Fig. 7.

Fig. 7

Plasma PK of MPL (top left panel), plasma insulin (top right panel), hepatic PEPCK protein (bottom left panel), and plasma glucose (bottom right panel) dynamics following a 10 mg/kg IV bolus of MPL. Circles are measurement from single rats and solid lines depict simulated predictions performed based on the developed model (Fig. 1) using parameters shown in Tables 1 and 3. Data were from a previous report. Reproduced with Permission from Jin and Jusko [23]