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. Author manuscript; available in PMC: 2020 Apr 20.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2018 Apr 27;45(4):557–575. doi: 10.1007/s10928-018-9585-x

Table 2.

Parameter estimates for tyrosine aminotransferase (TAT) dynamics

Parameter (units) Definition Estimate (% CV)
Tyrosine aminotransferase dynamics
 kd,TATm (h−1) Degradation rate constant for TAT mRNA 0.22 (66.6)
 SDRnTATm(nM−1) Stimulation constant for TAT mRNA synthesis 0.002 (48.1)
 kd,TAT (h−1) Degradation rate constant for TAT protein 0.29 (73.6)
 γ1 Amplification factor for TAT protein 4.5 (34.9)
 kd,TAT (h−1) Degradation rate constant for TAT activity 2.0 (96.0)
 γ2 Amplification factor for TAT activity 1.67 (11.8)
 TATm (0) Baseline TAT mRNA 0.87 (12.0)
 TAT (0) Baseline TAT protein 0.88 (12.8)
 TATa (0) (activity/mg protein) Baseline TAT activity 0.041 (7.3)