Table 3:

Results of logistic regression models of HiSCR achievement (Model 1) and IHS4 440 category change (Model 2) in patients treated with Adalimumab and Placebo in PIONEER 1 and PIONEER 2.

Variable	PIONEER 1 Achieving HiSCR			PIONEER 2 Achieving HiSCR
Model 1	Odds Ratio	95 % CI	P value	Odds Ratio	95 % CI	P value
Adalimumab	2.08	(1.25, 3.47)	0.005	4.23	(2.51, 7.31)	<0.001
Hurley Stage 3	0.91	(0.52, 1.59)	0.74	0.64	(0.37, 1.11)	0.11
Family History	0.77	(0.41, 1.40)	0.40	0.73	(0.39, 1.32)	0.30
Current Smoker	0.98	(0.59, 1.65)	0.94	0.56	(0.32, 1.0)	0.05
Presence of Draining Tunnels	0.63	(0.34, 1.18)	0.15	0.47	(0.26, 0.84	0.01
Antibiotic Use	-	-	-	0.48	(0.24, 0.95)	0.04
BMI	1.01	(0.97, 1.04)	0.74	0.93	(0.89, 0.97)	<0.001
Male Sex	0.85	(0.49, 1.47)	0.57	0.89	(0.49, 1.61)	0.70
Age	1.0	(0.97, 1.02)	0.73	1.0	(0.98, 1.02)	0.97
Variable	PIONEER 1 Achieving IHS4 Category Change			PIONEER 2 Achieving IHS4 Category Change
Model 2	Odds Ratio	95 % CI	P value	Odds Ratio	95 % CI	P value
Adalimumab	1.69	(1.00, 2.86)	0.05	2.91	(1.75, 4.92)	<0.0001
Hurley Stage 3	0.52	(0.30, 0.88)	0.02	0.57	(0.33, 0.95)	0.03
Family History	1.02	(0.55, 1.86)	0.96	1.25	(0.70, 2.22)	0.45
Current Smoker	0.82	(0.48, 1.39)	0.45	1.01	(0.58, 1.76)	0.97
Antibiotic Use	-	-	-	0.76	(0.39, 1.47)	0.42
BMI	1.02	(0.99, 1.06)	0.22	0.95	(0.91, 0.98)	0.006
Male Sex	0.73	(0.41, 1.29)	0.29	0.55	(0.31, 0.96)	0.04
Age	1.0	(0.98, 1.02)	0.94	0.99	(0.97, 1.02)	0.63