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. 2020 Jan 1;14(1):72–92.

Table 3(b).

Gene ontology (GO) profile after TSA, 5-Aza and TSA+5-Aza treatments in Kasumi 1

GO IDs
GO term
Genes
P-value
Biological processes
GO:0007155 Cell adhesion ADAM12, CDH15, COL1A1, PTPRK, PTPRF, DSC2, ATP1B2, CD96, DSC2, COL1A1, MCAM 0.00093
GO:0050900 Leukocyte migration ANGPTL1, COL1A1, ATP1B2, PECAM1, PTPN6, DOK2 0.0013
GO:0030282 Bone mineralization CLEC3B, WNT11, FGFR3, TUFT1 0.0014
GO:0008277 Regulation of G-protein coupled receptor protein signaling pathway GNG4, RGS18, RGS9,
RAMP1
0.0022
GO:2000147 Positive regulation of cell motility CCR7, CSF1R, TWIST1 0.0037
GO:0006909 Phagocytosis CEBPE, CD93, ELANE, PECAM1 0.0039
GO:0035335 Peptidyl-tyrosine dephosphorylation PTPN6, PTPN7, PTPRK,PTPRF, DUSP6 0.0042
GO:0034394 Protein localization to cell surface WNT11, ANGPTL1, PTPRK 0.0051
GO:0043066 Negative regulation of apoptotic process GLI3, WNT11, ANGPTL1, ANGPTL4, CSF1R, DHRS2, TWIST1, MYC 0.0068
GO:0006468 Protein phosphorylation FES, MOK, WNT11, CDK14, LMTK3, TRIB3, RPS6KA4 0.024
GO:0060548 Negative regulation of cell death WNT11, CST3, MYC 0.030
GO:0030097 Hematopoiesis ANGPTL1, CSF1R, GFI1 0.034
GO:0008285 Negative regulation of cell proliferation PTPN6, PTPRK, GL13, CSF1R, DHRS2, DLG3CBFA2T3 0.048
GO:0042493 Response to drug FOS, COL1A1, CST3, HDAC5, MYC 0.062
GO:0001525 Angiogenesis ANGPTL1, ANGPTL4, PECAM1, RAMP1, MCAM 0.096
GO:0007017 Microtubule-based process TUBB2A, TUBB3 0.10
Molecular Functions
GO:0004725 Protein tyrosine phosphatase activity PTPN6, PTPN7, PTPRF, PTPRK, DUSP6 0.0038
GO:0005001 Transmembrane receptor protein tyrosine phosphatase activity PTPN6, PTPRF, PTPRK 0.0051
GO:0030246 Carbohydrate binding CLEC3B, CLEC4B, PRG2, LGALS12 0.036
GO:0004672 Protein kinase activity MOK, TRIB3, CDK14, LMTK3, STK33, MAP3K9 0.078
GO:0008201 Heparin binding CLEC3B, ELANE, PTPRF, PRG2 0.081
GO:0004674 protein serine/threonine kinase activity MOK, SBK1, LMTK3, MAP3K9, RPS6KA4, STK33 0.091
GO:0008013 Beta-catenin binding GLI3, DACT3, PTPRK 0.095
GO:0003700 Transcription factor binding FOS, PBX2, HDAC5, TWIST1, MYC 0.100
Pathways
Transcriptional misregulation in cancer CEBPE, LMO2, CSF1R, CDK14, MYC, ELANE 0.0014
MAPK signaling pathway FOS, PTPN7, MYC, RPS6KA4 0.010
PI3K-Akt signaling pathway DDIT4, GNG4, ANGPTL1, COL1A1, CSF1R, FGFR3, MYC 0.041
Pathway in cancer FOS, GNG4, GLI3, WNT11, CSF1R, FGFR3, MYC 0.069
Hippo signaling pathway WWCI, WNT11, MYC, DLG3 0.10
Proteoglycans in cancer WNT11, PTPN6, TWIST1, MYC 0.18
Ras signaling GNG4, ANGPTL4, CSF1R, FGFR3 0.23
Phagosome TUBB2A, TUBB3 0.10

(DAVID software analysis, EASE score, p< 0.1)