Table 2.
Comparison of serum concentrations of biochemical factors between total haemophilia A patients and HCs, and between adults and children separately
| Variables |
Total
haemophilia A patients (n=85) |
HCs
n = 85 |
p |
Adults with haemophilia
A n = 58 |
Healthy adults
n = 58 |
p |
Children with
haemophilia A n = 27 |
Healthy
children n = 27 |
p |
|---|---|---|---|---|---|---|---|---|---|
| 25(OH)D, ng/mL |
21.4 ± 4.08 | 22.3 ± 3.95 | 0.147 | 22.06 ± 4.47 | 22.38 ± 3.85 | 0.68 | 19.97 ± 2.61 | 22.11 ± 4.21 | 0.03 |
| Zinc, µgr/dL | 64.55 ± 21.5 | 83.51 ± 26.97 | <0.001 | 65.45 ± 23.4 | 82.84 ± 25.09 | <0.001 | 62.62 ± 16.95 | 84.96 ± 31.08 | 0.002 |
| Phosphorus, mg/dL |
3.93 ± 0.66 | 4.84 ± 2.25 | <0.001 | 4.12 ± 0.61 | 5.01 ± 2.33 | 0.006 | 3.52 ± 0.59 | 4.48 ± 2.06 | 0.025 |
| Calcium, mg/dL |
8.45 ± 1.18 | 8.74 ± 0.97 | 0.09 | 8.5 ± 1.17 | 8.82 ± 1.04 | 0.117 | 8.36 ± 1.21 | 8.55 ± 0.78 | 0.494 |
| Magnesium, mg/dL |
1.69 ± 0.88 | 2.04 ± 0.81 | 0.007 | 1.87 ± 0.85 | 2.17 ± 0.81 | 0.063 | 1.29 ± 0.81 | 1.77 ± 0.76 | 0.028 |
| ALP, IU/L | 237.98 ± 68.33 | 142.25 ± 65.44 | <0.001 | 211.14 ± 56.12 | 121.45 ± 52.07 | <0.001 | 295.67 ± 55.82 | 186.92 ± 69.67 | <0.001 |
| PTH, pg/mL | 39.81 ± 24.66 | 34.91 ± 23.14 | 0.184 | 35.46 ± 22.29 | 32.17 ± 21.43 | 0.419 | 49.14 ± 27.26 | 40.82 ± 25.87 | 0.255 |
All data are shown as mean ± standard deviation, and analyzed by two-sample t test.
ALP, alkaline phosphatase; PTH, parathyroid hormone; HCs, healthy controls.