. 2019 Aug 22;61(8):768–776. doi: 10.1111/ped.13903

Table 3.

Univariate indicators of severe disease in pediatric EV‐D68 infection, TMCMC, September–October 2015 (n = 40)

	Severity†				ICU admission				Hospitalization duration (days)‡
	No	Yes	OR (95%CI)	P‐value	No	Yes	OR (95%CI)	P‐value	≤5	>5	OR (95%CI)	P‐value
Sex
Male	20	5	1.0 (−0.16 to 7.61)	0.65	23	2	1.22 (0.058–76.88)	1.00	15	10	0.44 (0.098–1.96)	0.18
Female	12	3	1.0 (−0.16 to 7.61)	0.65	14	1	1.22 (0.058–76.88)	1.00	6	9	0.44 (0.098–1.96)	0.18
Prematurity
Yes	4	0	NA	0.44	4	0	NA	0.80	1	3	4.0 (0.28–220.25)	0.32
No	28	7	NA	0.44	33	2	NA	0.80	20	15	4.0 (0.28–220.25)	0.32
History of asthma
Yes	11	3	0.59 (0.15–7.22)	1.00	13	1	0.92 (0.015–19.39)	1.00	9	5	0.48 (0.098–2.17)	0.33
No	21	5	0.59 (0.15–7.22)	1.00	24	2	0.92 (0.015–19.39)	1.00	12	14	0.48 (0.098–2.17)	0.33
History of CVD
Yes	1	1	4.43 (0.05–358.49)	0.36	1	1	18.0 (0.15–1,448.79)	0.15	0	2	NA	0.22
No	31	7	4.43 (0.05–358.49)	0.36	36	2	18.0 (0.15–1,448.79)	0.15	21	17	NA	0.22
History of NMD
Yes	2	1	2.14 (0.032–45.87)	0.50	3	0	NA	1.00	1	2	2.35 (0.11–145.62)	0.60
No	30	7	2.14 (0.032–45.87)	0.50	34	3	NA	1.00	20	17	2.35 (0.11–145.62)	0.60
Age (years)
<2	9	1	ref	ref	10	0	NA	ref	4	6	ref	ref
2–5	12	4	3.0 (0.28–31.63)	0.36	14	2		1.00	8	8	0.67 (0.13–3.30)	0.62
>5	11	3	2.45 (0.21–27.84)	0.47	13	1		1.00	9	5	0.37 (0.070–1.97)	0.24

^†ICU admission, use of magnesium sulfate, non‐invasive positive pressure or mechanical ventilation. ^‡Dichotomized according to the median. CVD, cardiovascular disease; EV‐D68, enterovirus D68; ICU, intensive care unit; NA, not applicable because of the small number of reports; NMD, neuromuscular disease; TMCMC, Tokyo Metropolitan Children's Medical Center.

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