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. 2015 Nov 17;51(6):613–623. doi: 10.1002/ppul.23342

Table 3.

Analysis of Risk Factors for LOS (nmax = 232)

Univariate Multivariate
Risk factors present on admission Difference in median LOS (hours) * 95%CI P‐value Difference in median LOS (hours) * 95%CI P‐value
Continuous Spearman correlation
Age (months) −0.2 −1.2 (−2.1, −0.2) 0.02 −0.6 (−1.6, 0.5) 0.3
Gestational age (weeks) 0.09 0.7 (−0.7, 2.0) 0.3
Birth weight (kg) 0.03 −0.0 (−5.7, 6.2) 0.9
Severity score on admission (points) 0.2 3.1 (1.1, 5.1) 0.002 3.0 (0.7, 5.1) 0.01
Categorical Geometric mean LOS (hours)
Gender
Female 61 −1.4 (−9.4, 8.0) 0.8
Male 62 (reference)
Currently breastfed
Yes 62 1.9 (−8.9, 15.1) 0.7
No 60 (reference)
Previous respiratory hospitalisation
Yes 60 −2.0 (−11.1, 9.0) 0.7
No 62 (reference)
Mother smoked during pregnancy
Yes 62 1.7 (−6.6, 11.4) 0.7
No 60 (reference)
Exposed to household smoke
Yes 62 0.2 (−8.0, 9.8) 0.9
No 61 (reference)
Antibiotics before hospitalisation
Yes 61 −7.1 (−14.4, 1.4) 0.09 −2.4 (−11, 7.6) 0.6
No 69 (reference)
Any virus detected
Yes 64 8.7 (−1.9, 21.3) 0.11
No 55 (reference)
RSV
Yes 66 7.0 (−2.2, 17.2) 0.14 10.0 (−0.6, 22.3) 0.06
No 58 (reference)
HRV
Yes 64 3.4 (−6.1, 14.6) 0.5
No 61 (reference)
RSV and HRV
Yes 64 5.0 (−3.8, 15.1) 0.3
No 59 (reference)
Adenovirus
Yes 57 −4.4 (−18.3, 14.3) 0.6
No 62 (reference)
Any bacteria detected
Yes 63 3.1 (−5.7, 13.4) 0.5
No 59 (reference)
Virus/bacteria interaction 0.3
Virus negative/Bacteria negative 58 (reference)
Virus negative/Bacteria positive 53 −5.0 (−19.1, 14.2) 0.6
Virus positive/Bacteria negative 60 1.5 (−13.2, 21.0) 0.9
Virus positive/Bacteria positive 65 7.0 (−7.9, 26.0) 0.4

On univariate analysis, factors at enrolment associated with prolonged LOS were age and severity score. On multivariate analysis, only severity score remained significant.

*

Arising as a re‐expression of the multiplicative effect on the geometric mean from a linear regression on log (LOS).