Figure 1.

 The effect of intracellular localisation and modification on the accumulation of HIV‐1 Gag‐derived p41. (a) Depiction of Pr⁵⁵Gag precursor polyprotein translated from the gag gene of HIV‐1. MA or p17 is the matrix protein, myristylated at position 2; CA or p24 is the isometric capsid protein; NC or p7 is the nucleocapsid protein; p6 is an accessory protein, which mediates interactions between Pr⁵⁵Gag and Vpr. P41 is a truncated version of Pr⁵⁵Gag comprising only p17 and p24. (b) Transient expression of HIV‐1 p41 (p17::p24) protein in Agrobacterium‐infiltrated N. benthamiana was measured by commercial HIV‐1 p24 ELISA test [described by (Meyers et al., 2008)] 4 days after infiltration. G2A‐p41 is p41 mutated by Gly‐>Ala replacement at position 2: this removes the myristylation signal. Figure adapted from Meyers et al. (2008).