Figure 4.

In the brain (A), ACE2 is expressed only in endothelium (arrow) and vascular smooth muscle cells. In the liver (B), Kupffer cells, hepatocytes, and the endothelium of sinusoids are negative. Luminal staining in bile ducts is occasionally observed (arrow‐head). Vascular endothelium (arrow) and smooth muscle cells are positive. In the spleen (C), ACE2 is not expressed in cells of the immune system. Vascular and red pulp sinus endothelium is positive. In the kidney (D), ACE2 is present in glomerular visceral (arrow) and parietal (arrow‐head) epithelium, in the brush border (short arrow) and cytoplasm of proximal tubular cells, and in the cytoplasm of distal tubules and collecting ducts