Figure 4.

Immunohistochemical staining pattern of ACE2 in the kidney. In the healthy human kidney (A), ACE2 is predominantly present in the brush border of proximal tubular cells (arrow) and to a lesser extent in the glomerular visceral and parietal epithelium. In rat kidney (B), ACE2 is predominantly found in glomeruli and to a lesser extent in distal tubules (open arrow). In mouse kidney (C), the distribution pattern of ACE2 is comparable to human kidney with predominant expression in proximal tubules (arrow). ACE2 is also expressed during human nephrogenesis (gestational age 16 weeks) (D)