Table 1.

Examples of fusion proteins and peptides

Enveloped viruses
Class	Characteristic features	Virus	Fusion peptide sequence
Class I	• Trimeric in pre‐and post‐fusion conformation; • synthesized as inactive precursor, proteolytic cleavage required for fusogenic activity; • N‐terminal fusion peptide; • formation/extension of an α‐helical coiled‐coil propels the fusion peptide toward the target membrane; • postfusion conformation contains a heptad repeat‐derived six helix bundle core structure.	Influenza	GLFGAIAGFIENGWEGMIDGWYG
		HIV	AVGIGALFLGFLGAAGSTMGARS
		Ebola	GAAIGLAWIPYFGPAAE
Class II	• Dimeric and parallel to the viral envelope in pre‐fusion conformation, and trimeric post‐fusion conformation; • fusion peptides are loops buried in the dimer interface; • post‐fusion trimeric complexes.	Dengue	DRGWGNGCGLFGKGSL
		Simian foamy	VYTGVYPFMWGGAYCFCDS
Class III	• Trimeric in pre‐ and post‐fusion conformation; • fusion loops positioned toward the viral envelope; • postfusion structure resembles six‐helix bundle of class I proteins, without heptad repeat domains	Rhabdovirus G	WY/YA
		Herpes virus gB	VWFGHRY/RVEAFHRY
		Baculovirus gp64	YAYNGGSLDPNTRV/VKRQNNNHFAHHTCNK
Non‐enveloped viruses
Peptide name	Virus	Lytic peptide sequence
γ peptide	Flock house virus	ASMWERVKSIIKSSLAAASNIPGPIGVAASGISGLSALFEGFGF
γ1 peptide	Flock house virus	ASMWERVKSIIKSSLAAASNI
VP4 peptide	Poliovirus	MNMSRQGIFQTVGSGLDHILSLA
μ1N peptide	Reovirus	MGNASSIVQTINVTGDGNVFKPSAETSSTAVPSLSLSPGMLN