Figure 1.

Disordered antigens are bona fide targets of antibody recognition. A, Epitopes within disordered protein regions are more likely to be targets of positive antibody binding assays. B, Antibodies to disordered epitopes (purple) and ordered epitopes (green) are subject to similar levels of somatic hypermutation. C, Disorder accounts for only a small fraction of the variability in antibody affinity. D, Disordered epitopes (purple) are exclusively short linear epitopes, while ordered epitopes (green) are predominantly conformational epitopes spanning many residues in the primary sequence. Modified with permission from Ref. 43