Table 1.
Baseline population characteristics
| All Patients (n = 16 578) | MACE occurred (n = 1842) | No MACE (n = 14 736) | P-value | |
|---|---|---|---|---|
| Age (years), mean ± SD | 64.2 ± 12.2 | 70.4 ± 12.0 | 63.4 ± 12.0 | <0.001 |
| Male, n (%) | 9846 (59.4) | 1184 (64.3) | 8662 (58.8) | <0.001 |
| Site, n (%) | ||||
| Assuta | 5137 (31.0) | 486 (26.4) | 4651 (31.6) | <0.001 |
| Brigham and Women’s | 2280 (13.8) | 353 (19.2) | 1927 (13.1) | <0.001 |
| Cedars-Sinai | 3297 (19.9) | 487 (26.4) | 2810 (19.1) | <0.001 |
| Oregon | 2477 (14.9) | 331 (18.0) | 2146 (14.6) | <0.001 |
| Ottawa | 3387 (20.4) | 185 (10.0) | 3202 (21.7) | <0.001 |
| Body mass index (kg/m2), median (IQR) | 27.3 (24.5–31.0) | 26.9 (23.9–30.8) | 27.4 (24.6–31.0) | <0.001 |
| Past medical history, n (%) | ||||
| Hypertension | 10 652 (64.3) | 1407 (76.4) | 9245 (62.7) | <0.001 |
| Diabetes | 4250 (25.6) | 704 (38.2) | 3546 (24.1) | <0.001 |
| Dyslipidaemia | 10 461 (63.1) | 1263 (68.6) | 9198 (62.4) | <0.001 |
| Current smoker | 3404 (20.5) | 361 (19.6) | 3043 (20.7) | 0.298 |
| PVD | 2204 (13.3) | 379 (20.6) | 1825 (12.4) | <0.001 |
| Prior MI | 2527 (15.2) | 441 (23.9) | 2086 (14.2) | <0.001 |
| Prior revascularization | 4521 (27.3) | 705 (38.3) | 3816 (25.9) | <0.001 |
| Family history of CAD, n (%) | 4655 (28.1) | 405 (22.0) | 4250 (28.8) | <0.001 |
| Typical angina, n (%) | 1019 (6.2) | 114 (6.2) | 905 (6.1) | 0.918 |
| Resting vital signs | ||||
| Systolic BP (mmHg), median (IQR) | 130 (120–146) | 134 (120–150) | 130 (120–145) | <0.001 |
| Diastolic BP (mmHg), median (IQR) | 80 (74–84) | 80 (70–81) | 80 (74–84) | <0.001 |
| Heart rate (bpm), median (IQR) | 68 (60–77) | 70 (61–80) | 68 (60–77) | <0.001 |
| Exercise stress, n (%) | 7489 (45.2) | 441 (23.9) | 7048 (47.8) | <0.001 |
| Pharmacologic stress, n (%) | 9089 (54.8) | 1401 (76.1) | 7688 (52.2) | <0.001 |
BP, blood pressure; bpm, beats per minute; CAD, coronary artery disease; IQR, interquartile range; MI, myocardial infarction; PVD, peripheral vascular disease; SD, standard deviation.