Table 4.

Multivariable models of associations with mace stratified by ischaemia categories

	No ischaemia (ischaemic TPD <1%)		Minimal (< 5% ischaemic TPD)		Mild (5 to <10% ischaemic TPD)
Variables	Adjusted HR (95% CI)	P-value	Adjusted HR (95% CI)	P-value	Adjusted HR (95% CI)	P-value
Age (years)	1.04 (1.03–1.05)	<0.001	1.04 (1.03–1.05)	<0.001	1.03 (1.02–1.04)	<0.001
Male	1.89 (1.55–2.31)	<0.001	–	–	–	–
Body mass index	0.96 (0.94–0.98)	<0.001	0.98 (0.97–0.99)	0.002	–	–
Hypertension	1.42 (1.12–1.80)	0.004	–	–	–	–
Diabetes	1.46 (1.17–1.83)	0.001	1.80 (1.55–2.09)	<0.001	1.33 (1.11–1.59)	0.002
Prior MI	1.49 (1.08–2.07)	0.016	1.29 (1.07–1.56)	0.008	1.23 (1.02–1.50)	0.034
Family history	–	–	0.76 (0.64–0.92)	0.004	–	–
Typical angina	–	–	0.66 (0.46–0.95)	0.026	–	–
Exercise stress	0.43 (0.34–0.55)	<0.001	0.54 (0.45–0.65)	<0.001	0.53 (0.42–0.67)	<0.001
Reduced LVEF	–	–	1.37 (1.04–1.82)	0.028	1.75 (1.37–2.23)	<0.001
Shape index	–	–	1.03 (1.02–1.04)	<0.001	1.03 (1.01–1.04)	<0.001
TID	1.80 (1.23–2.63)	0.002	1.23 (0.88–1.70)	0.223	1.50 (1.02–2.21)	0.037
Post-stress WMA	1.11 (0.77–1.61)	0.582	1.24 (1.03–1.50)	0.024	0.92 (0.75–1.13)	0.440

– indicates variable not included in model.

CAD, coronary artery disease; HR, hazard ratio; LVEF, left ventricular ejection fraction; MI, myocardial infarction; TID, transient ischaemic dilation; WMA, wall motion abnormality.