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. 2015 Dec 4;51(3):225–242. doi: 10.1002/ppul.23351

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© 2015 Wiley Periodicals, Inc.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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(Modified with permission from Chang AB, Redding GJ, and Everard ML. (2008), Chronic wet cough: protracted bronchitis, chronic suppurative lung disease and bronchiectasis. Pediatr Pulmonol;43:519–531; doi: 10.1002/ppul.20821) Using the pathobiologic model, protracted bacterial bronchitis (PBB), chronic suppurative lung disease (CSLD), and radiographic‐confirmed bronchiectasis likely represents different ends of a spectrum with similar underlying mechanisms of airway neutrophilia, endobronchial bacterial infection, and impaired mucociliary clearance. Untreated it is likely some (but not all) children with PBB will progress to develop CSLD and some will ultimately develop bronchiectasis, initially reversible and subsequently irreversible if left to progress. There is a degree of overlap between each of the entities.