. 2015 Feb 6;15(5-6):1075–1088. doi: 10.1002/pmic.201400386

Table 2.

Examples of cytosolic/periplasmic proteases found in microbial exoproteomes

Protease	NCBI locus	Organism	Reference	Additional conversed domains
Aminopeptidase I	BB0366	Borrelia burgdorferi	126
Aminopeptidase M	XP_001682593	Leishmania major	127
Aminopeptidase N	AAK99510 ZP_01769994 ADG61634	Streptococcus pneumoniae Burkholderia pseudomallei Moraxella catarrhalis	123 128 129
Aminopeptidase T	NP_830199	Bacillus cereus	130
Carboxypeptidase	Q18AU1_CLOD6	Clostridium difficile	131	Aminoacylase 1
C‐terminal processing peptidase	BP0609	Bordetella pertussis	132
ClpB	BP1198 NP_371049	Bordetella pertussis Staphylococcus aureus	132 133	AAA⁺ ATPase
ClpC	AAT29160	Bacillus anthracis	134	AAA⁺ ATPase
ClpP	BB2254 ZP_21019400 NP_371292	Bordetella bronchiseptica Escherichia coli Staphylococcus aureus	132 133 133	AAA⁺ ATPase
Collagenase	YP_005053876	Filifactor alocis	136
Deblocking aminopeptidase	NP_834277	Bacillus cereus	130
DPPIII	XP_001687573	Leishmania major	127
DPPIV	BP0906 AAL80949 XP_001681251	Bordetella pertussis Pyrococcus furiosus Leishmania major	132 137 127
DPPVII	YP_004045754	Riemerella anatipestifer	138
Endopeptidase O	AAL00295	Streptococcus pneumoniae	123
Glutamyl aminopeptidase	AAL00485	Streptococcus pneumoniae	123
HtrA	OE7_04918 BP2434 P0C0V0 CAB13147 CAD00819 ? BB0104	Haemophilus parasuis Bordetella pertussis Escherichia coli Bacillus subtilis Listeria monocytogenes Brucella abortus Borrelia burgdorferi	139 132 140 141 142 143 126
l‐Aminopeptidase d‐amidase/d‐esterase	YP_005055390	Filifactor alocis	136	Endo‐type 6 aminohexanoate‐oligomer hydrolase
Leucine aminopeptidase	XP_001681531	Leishmania major	127
Lon protease	YP_005054101	Filifactor alocis	136	AAA⁺ ATPase
Oligopeptidase F	AAT30293/ AAT30449	Bacillus anthracis	134
O‐Sialoglycoprotein endopeptidase	YP_005054583	Filifactor alocis	136	Molecular chaperone
Peptidase T	NP_833858 CAB15918 AAT33487	Bacillus cereus Bacillus subtilis Bacillus anthracis	130 141 134
Protease 1	PFPI_PYRFU	Pyrococcus furiosus	137	Glutamine aminotransferase
Protease HsIV	YP_513676	Francisella tularensis	144
Pyroglutamyl peptidase	YP_513002	Francisella tularensis	144
Signal peptide peptidase A	YP_514244	Francisella tularensis	144
TAP	P0ADA1	Escherichia coli	139
Thermostable carboxypeptidase	NP_831344 CBP1_PYRFU XP_001686015	Bacillus cereus Pyrococcus furiosus Leishmania major	130 137 127
Thimet oligopeptidase	XP_001684161	Leishmania major	127
Transpeptidase	ZP_21022097	Escherichia coli	135	Transglycosylase
Xaa‐His dipeptidase	NP_372275	Staphylococcus aureus	133
Xaa‐Pro aminopeptidase	CBA64059/ CBA64694 XP_003722629	Clostridium difficile Leishmania major	131 127	Creatinase Prolidase
Zinc metallopeptidases	BP1721 CD630_28300 XP_001685175 BB0627	Bordetella pertussis Clostridium difficile Leishmania major Borrelia burgdorferi	132 145 127 126	LysM Acetylornithine deacetylase

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