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. 2014 Dec 11;235(2):175–184. doi: 10.1002/path.4458

Figure 3.

PATH-4458-FIG-0003-c

Histopathology and in situ detection of MERS‐CoV in the lungs of a cynomolgus macaque after intratracheal inoculation with MERS‐CoV. (A) The alveolar septa are mildly thickened, with infiltration of a few neutrophils and monocytes. There are also increased numbers of intraluminal alveolar macrophages and a few neutrophils; H&E, magnification = ×10. (B). MERS‐CoV specific RNA by in situ hybridization (ISH), targeting the MERS‐CoV nucleocapsid, is present in lung tissue of of a cynomolgus macaque after intratracheal inoculation with MERS‐CoV. RNA is present predominantly in type II alveolar epithelial cells, with less in type I epithelial cells; ISH, magnification = ×10.