Table 3.
Univariate analysis of effects of prednisolone for primary and secondary outcomes
Outcome | n | p‐values for prednisolone vs. placebo in all patients and for interactions between study drug and different variables | |||||||
---|---|---|---|---|---|---|---|---|---|
All patients | Age | Atopy | B‐eos | Picornavirus | Rhinovirus | Enterovirus | RSS at entry* | ||
Time until ready for discharge, h | 58 | 0.71 | 0.034 | 0.15 | 0.73 | 0.026 | 0.050 | 0.0002 | 0.20 |
Duration of cough, days | 50 | 0.12 | 0.97 | 0.091 | 0.079 | 0.93 | 0.033 | 0.28 | 0.40 |
Duration of dyspnea, days | 50 | 0.61 | 0.80 | 0.057 | 0.42 | 0.24 | 0.019 | 0.50 | 0.96 |
Outpatient visit, no.† | 46 | 0.99 | 0.82 | 0.77 | 0.83 | 0.94 | 0.92 | 0.79 | 0.77 |
Rehospitalized, no.† | 46 | 0.89 | 0.94 | 0.84 | 0.90 | 0.98 | 0.89 | 0.86 | 0.87 |
B‐eos at discharge, ×109/l | 53 | <0.0001 | 0.71 | 0.80 | 0.22 | 0.79 | 0.72 | 0.60 | 0.41 |
B‐eos 2 wk after discharge, ×109/l | 52 | 0.24 | 0.45 | 0.91 | 0.33 | 0.76 | 0.24 | 0.74 | 0.51 |
B‐Eos, blood eosinophils.
Values are medians (interquartile range) or number of subjects (%). Analysis using multivariate regression analysis.
*Respiratory symptoms scores (RSS) were assessed on a scale from 0 (none) to 12 (severe) at study entry.
†As a result of wheezing during 2 months after discharge.