Table 3.
Recombinant antibodies derived by phage display against eukaryotic pathogens
| Eukaryotic pathogen | Target | Library type | Antibody format | Antibody origin | Application | Reference |
|---|---|---|---|---|---|---|
| Aspergillus fumigatus | Crf2 | Immune/naïve | scFv, scFv‐Fc | Macaque/human | ELISA, IF | 41 |
| Aspergillus niger | Glucose oxidase | Semisynthetic | scFv | Human | ELISA | 165 |
| Babesia gibsoni | P50 | Semisynthetic | scFv | Human | ELISA, IF | 164 |
| Candida albicans | Als3p and other | Naïve | scFv | Human | ELISA, IF, immunoblot, in vitro neutralization | 266, 267, 268 |
| Cryptosporidium parvum | P23 | Semisynthetic | scFv | Human | ELISA | 158 |
| Cryptosporidium parvum | S16 | Semisynthetic | scFv | Human | ELISA | 159 |
| Fusarium verticillioides | Cell wall‐bound proteins | Immune | scFv | Chicken | ELISA, IF | 166 |
| Fusarium verticillioides | Soluble cell wall‐bound proteins | Immune | scFv, scFv‐AP | Chicken | ELISA, IF, immunoblot | 269 |
| Myxobolus rotundus | Spore protein | Immune | scFv | Mice | ELISA, in vitro neutralization | 163 |
| Plasmodium chabaudi | AMA‐1 | Immune | scFv | Mice | ELISA, immunoblot | 168 |
| Plasmodium falciparum | MSP‐1 | Immune | scFv | Human | ELISA, IF | 180 |
| Plasmodium falciparum | MSP‐3 | Immune | Fab, IgG | Human | ELISA, IF, immunoblot, FACS | 161 |
| Plasmodium falciparum | Pfs48/45 | Immune | scFv | Human | ELISA, immunoblot | 160 |
| Plasmodium yoelii | MSP1 | Immune | scFv | Mice | ELISA, immunoblot, in vivo protection | 270 |
| Sclerotinia sclerotiorum | SSPG1d | Immune | scFv | Mice | ELISA, immunoblot | 167 |
| Strongyloides venezuelensis | HSP60 | Presumably naïve | scFv | Human | ELISA, IF | 271 |
| Taenia solium | TS14 | Immune | VHH | Camel | ELISA, immunoblot | 272 |
| Taenia solium | T. solium metacestodes, peptides | Naïve | scFv | Human | ELISA, IF | 157 |
| Trypanosoma evansi | Different surface proteins | Immune | VHH | Camel | ELISA, FACS | 169 |
| Toxoplasma gondii | TgMIC2 | Immune | scFv | Mice | ELISA, immunoblot | 162 |
ELISA, enzyme‐linked immunosorbent assays; IHC, immuno histo chemistry; IF, immuno fluorescence microscopy; FACS, fluorescence‐activated cell sorting.
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