Figure 4.

Absolutely conserved SmSte24 residues mapped to the Tripartitie Architecture of Ste24. The topology diagram “backbone” is gray scale shaded as in Figure 3D. Functional roles of 17 of the 38 residues can be assigned via comparisons to structural and/or functional characterization of themolysin (M4), neprilysin (M13), and the G sulfurreducens ZMP (M48) and are displayed as black oval with white font (also see Table 1). The remaining 21 residues, whose structural and functional homology to gluzincins is currently lacking or are unique to the Step24 family, are displayed as white ovals with black font