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Differential H&E and immunohistochemical features between clear cell tubulo-papillary renal cell carcinoma (cctpRCC) and clear cell carcinoma (ccRCC). cctpRCC shows a peculiar tubular structure with little atypia and nuclei lined over the basal membrane, diffuse cytokeratin 7 (Ck7) reactivity, and negativity for racemase. ccRCC shows irregular nests of clear cells negative for both CK7 and racemase (scale bar 100 microns).
