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. 2020 Jan 3;9(1):17. doi: 10.3390/antibiotics9010017

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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New in vivo model of daptomycin action. (A) Molecular model of membrane interaction and protein delocalization. Adapted from [54]. (B) Corresponding microscopy pictures showing phase contrast and DiIC12 fluorescence. DiIC12 is a fluid lipid domain dye that visualizes regions of increased fluidity (RIFs) in both Gram-positive and Gram-negative bacteria [96,97]. Images were previously published in [54]. (C) Fluid membrane domains (indicated by arrows) stained with DiIC12 in different Gram-positive bacteria: B. subtilis, S. aureus, and Streptococcus pneumoniae. Images were previously published in [98]. (D) Accumulation of fluid membrane domains (arrows) by daptomycin in S. aureus. Scale bars: 2 µm.